The promising health benefits without the “high” or severe side effects make CBD an appealing alternative or adjunct to prescription medications. hemp oil However, like with all drugs, consideration of possible drug-drug and drug-food interactions is necessary. Although we don’t have conclusive evidence, it’s possible cannabis may work together with other drugs favorably. But, by the same token, there could be a risk that cannabis combined with other drugs could lower glucose levels too much.
Drugs which can increase the serotonin level when taken in combination with SSRIs include tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), carbamazepine, lithium or serotonergic substances. Given that the studies on CBD interactions with antidepressants are limited, it is not easy to conclude what can potentially happen when a dose of CBD is taken with antidepressants like Zoloft.
Always check with your licensed physician or prescribing doctor before using CBD if you are concerned. Also, a holistic doctor or someone in the Chinese medicine field might be able to answer some of your questions and be more versed in the land of CBD. I have attached a link that can help provide a bit of information as well. I can also provide you with an awesome link to connect you with a doctor who specializes in this and can provide a more personalized recommendation for you.
Likewise, the more CBD a product contains, the cheaper it is going to generally cost per mg. Unlike nicotine e-juice, the price of CBD oil is determined by potency rather than overall volume. In other words, you can have two equal-sized bottles of CBD oil, but the more potent one can potentially cost 2-3 times more, based on the total CBD content.
Hemp-derived CBD oil is safe for most users, largely because CBD leaves your system fairly quickly, and the negative side effects of CBD are relatively few, but CBD drug interactions raise concerns about your health. When you take blood-thinning medications, likeWarfarin, you may have side effects or interactions with the hemp oil. Studies into the use of blood thinners and CBD oil show that it actually increases the amount of the blood thinner in the blood. The major cannabanoids, THC and CBD are both metabolized in the liver by the CYP450 enzymes 2C9, 2C19 and 3A4. Drugs that inhibit these enzymes may enhance or prolong the effects of THC and CBD.
Neurological and physical examinations, blood and urine analysis, ECG and EEG were performed at weekly intervals. In phase 2 of the study, 15 patients suffering from secondary generalized epilepsy with temporal focus were randomly divided into two groups. Each patient received, in a double-blind procedure, mg daily of CBD or placebo.
In a study from 2015, children with seizure disorders were given CBD as a co-therapy to clobazam, an anti-seizure drug. The result was that the doctors were able to reduce the clobazam dosage, because CBD elevated the pharmaceutical’s plasma levels. On average, participants were able to reduce their clobazam intake with 1 mg/kg daily, and this helped alleviate the drug’s side effects. Once CBD enters the liver, the cannabinoid takes up nearly all of its P450 enzyme-processing capability, so to speak. In this way, it keeps the liver from breaking down any other hepatically-metabolized drugs.
My prescription gets a good 8+ hours to work as I sleep without any other supplements competing then when I wake I take it as needed. I have combined them at night on a few occasions but don’t like to risk the CBD effecting my thyroid meds.
Since your doctor already knows you are using cannabis and CBD and has approved, we recommend you discuss this with her as well. She knows your medical history and will be the best person to get feedback from about changing dosages or delivery methods. I have been using THC CBD combination, equal amounts of both in a cartridge which has helped me sleep soundly. But in the last month I have been experiencing insomnia and it does not seem to help.
CBD and its primary active metabolite 7-hydroxy CBD (7-OH-CBD) have similar reported effects on a number of CYP450 enzymes. CYP450 enzymes are implicated in the primary metabolism and biotransformation of the majority of therapeutic agents and xenobiotics . Each product label reported, to varying degrees, CBD activity on one or more CYP450 isoforms including 3A4, 2C9, 2C19, 1A2, 2C8, 2B6, and 2E1 .